Coverage

Basepair watches these gene and drug pairs, sourced from CPIC. Backed by 2,115 rules across 22 genes.

Gene	Drug	Phenotypes	Severity	On approve	Source
CYP2C19	Clopidogrel	Ultrarapid, rapid, intermediate, and poor metabolizers	Critical	Switch to prasugrel	CPIC Guideline: CYP2C19 and Clopidogrel (PMID 35034351)
SLCO1B1	Simvastatin	Decreased and poor function	Critical	Switch to pravastatin	CPIC Guideline: SLCO1B1, ABCG2, CYP2C9, and Statins (PMID 35152405)
TPMT + NUDT15	Azathioprine	Intermediate and poor metabolizers	Critical	Dose change, prescriber notified	CPIC Guideline: TPMT, NUDT15 and Thiopurines (PMID 41618934)
TPMT + NUDT15	Mercaptopurine	Intermediate and poor metabolizers	Critical	Dose change, prescriber notified	CPIC Guideline: TPMT, NUDT15 and Thiopurines (PMID 41618934)
TPMT + NUDT15	Thioguanine	Intermediate and poor metabolizers	Critical	Dose change, prescriber notified	CPIC Guideline: TPMT, NUDT15 and Thiopurines (PMID 41618934)
DPYD	Fluorouracil	Intermediate and poor metabolizers	Critical	Avoid, prescriber notified	CPIC Guideline: DPYD and Fluoropyrimidines (PMID 29152729)
DPYD	Capecitabine	Intermediate and poor metabolizers	Critical	Avoid, prescriber notified	CPIC Guideline: DPYD and Fluoropyrimidines (PMID 29152729)